Expression of Interest

Contact Person/Scientist in Charge

  • Name and surname: Teresa Roldán Arjona
  • Email: ge2roarmSPAMFILTER@uco.es

Universidad de Córdoba

Department / Institute / Centre

  • Name: Universidad de Córdoba. Departamento de Genética
  • Address: Campus de Rabanales. Edificio Gregor Mendel 14071
  • Province: Córdoba

Research Area

  • Life Sciences (LIF)

Brief description of the institution:

The Universidad de Córdoba (UCO) is a non-profit High Education and Research institution established in 1972. This University is considered at the forefront of research in Andalusia and is ranking among the top research institutions at the national level.
The research efforts are compound of 193 research units and 2.500 employees, covering different disciplines range from the Humanities, Legal and Social Sciences to the Health Sciences and Science and Technology.
Our institution is also involved in The Agrifood Campus of International Excellence (ceiA3) as well as in several research centers as the IMIBIC (Institute Maimonides of Biomedical Research) and the “University Research Institute of Fine Chemicals and Nanochemistry” and in the creation of the Rabanales 21 Science and Technology Park.
UCO is also equipped with cutting-edge centralized research facilities which are located on Rabanales Campus. These facilities include a Scanning Confocal Electron Microscope (SCEM), a Genomics and Proteomics Unit, A NIR/MIR Spectroscopy Unit, a Mass Spectrometry Unit, a Nuclear Magnetic Resonance Unit, among others. The university also has greenhouses, its own meteorology station and a Central Animal Experimentation Unit which complies with national and European legislation concerning research with genetically modified animals.
Our University has considerable experience in managing and implementing international projects: FP2-Fp7; H2020; ERA-NET; LIFE; COST; INTERREG...

Brief description of the Centre/Research Group (including URL if applicable):

The GC-22-EPIGENETIC group is composed by 1 research scientist, 4 postdocs and 2 students. The lab, internationally recognized, studies the relevance of the base repair system in the maintenance and control of genetic and epigenetic information. The fellow will join a dynamic group that utilizes state of the art techniques to study epigenetics.

Current research lines:

  • Molecular dissection of the base excising repair (BER) pathway in plants
  • Molecular characterization of the active DNA demethylation pathway in plants
  • Epigenetics and Cancer
  • Epigenetic Reprogramming

Recent publication:

Parrilla-Doblas, J.T., Ariza, R.R., and Roldan-Arjona, T. (2017). Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain. Epigenetics 12, 296-303.

Li, Y., Córdoba-Cañero, D., Qian, W., Zhu, X., Tang, K., Zhang, H., Ariza, R.R., Roldán-Arjona, T., and Zhu, J.K. (2015). An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis. PLoS genetics 11, e1004905.

Córdoba-Cañero, D., Roldan-Arjona, T., and Ariza, R.R. (2014). Arabidopsis ZDP DNA 3'-phosphatase and ARP endonuclease function in 8-oxoG repair initiated by FPG and OGG1 DNA glycosylases. Plant J 79, 824-834.

Martinez-Macías, M.I., Cordoba-Cañero, D., Ariza, R.R., and Roldan-Arjona, T. (2013). The DNA repair protein XRCC1 functions in the plant DNA demethylation pathway by stimulating cytosine methylation (5-meC) excision, gap tailoring, and DNA ligation. J Biol Chem 288, 5496-5505.

Info

Project description:

Our scientific activity is focused on the study of the mechanisms involved in maintaining genome and epigenome stability. Our group has found genetic and biochemical evidence for the existence of a mechanism for active demethylation of DNA in plants. We have identified a family of proteins, whose prototype is ROS1 and DME, which exhibit 5-methycytosine-DNA glycosylase activity, and initiate the deletion of 5-meC by a mechanism analogous to the Base Excision Repair (BER). Using genetic and molecular approaches, we have characterized in detail the biochemical activity of this new family of enzymes. In addition, we have identified other proteins involved in this mechanism of epigenetic reprogramming. We are currently investigating the relevance of the base DNA repair system in the maintenance and control of genetic and epigenetic information. In addition, we are analysing the relationship between this DNA demethylation pathway and different chromatin modifications. Finally, we are exploring the feasibility of using ROS1 and DME proteins to perform controlled DNA demethylation in plants for biotechnological purposes.

Applications

Candidates are encouraged to send their ideas and suggestions linked to our research lines to be discussed. Please send also a letter of motivation, short CV and two letters of reference to Teresa Roldan Arjona: ge2roarm@uco.es.

IMPORTANT: Applicants should check their CV against the eligibility and mobility conditions of Marie Skłodowska-Curie Actions

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